Friday 22 April 2022

Meet CBDiablo, the brand doing good by being a little bit bad

“Sleepless nights, endless stress, and the monthly merry-go-round of shit.” If you’ve ever run your own business, you will know it can be an endurance challenge at the best of times, and lead to burnout at worst. But for two enterprising friends, the slog of running a business led to the invention of a purpose-driven CBD brand.

After leaving university together, Ian and Sam, the founders of CBDiablo, found themselves running a profitable but challenging digital marketing agency. It was thanks to this agency that the pair became passionate about CBD, but not before a perception shift. While they enjoyed working on the client and generating results, they had some initial misgivings.

“We learned a lot about CBD, cannabis, and the culture by writing and reading about the subject every day,” says Ian. “From a nark hall assistant at University who always thought cannabis was harmful, I broke down all of my preconceptions and started to really love the nuance of the plant.”

From a nark hall assistant at University who always thought cannabis was harmful, I broke down all of my preconceptions and started to really love the nuance of the plant.

It was thanks to this change in attitude, and the dreaded burnout from the “digital marketing hamster wheel” that the CBD brand was formed. “We decided that we needed to leave the digital marketing industry and pursue a business focused around our newfound passion for CBD. We had lots of ideas that we’d floated with the client which they didn’t want to try, so we thought we’d try them ourselves. We made the hard decision to let the client know our plans and we started the foundations of CBDiablo.”

It’s clear to see the duo have come at the industry with a unique eye. Shunning the traditional green and white medical-style branding, instead opting for a playful, rebellious and sometimes cheeky approach, with an ethos styled around the battle of good vs evil. “The idea originally was a play on the concepts that surround cannabis itself,” Ian tells us. “Every brand we saw seemed to be a little scared of the cannabis part of CBD, but we leaned into it and embraced the negative connotations; challenging them head-on. We knew that it would put lots of people off but we knew that lots of people would love it.”

The battle of good vs evil isn’t just a cheap marketing gimmick for the brand, it’s also a driving force for success. Ian and Sam both agreed that they wanted to wake up in the morning feeling like they had more of a reason to work hard, they wanted a company more about having fun and living a fulfilled existence than just making a quick buck. As a result, the founders made a pledge to donate 20% of profits from CBDiablo to the mental health charity CALMzone. It’s a charity close to both the founders’ hearts, as well as having 5 brothers and 2 fathers between the pair, Ian tells us that bullying, anxiety, depression and ill-health had a big impact on his life in his early years. Doing good from cannabis played straight into the brand’s core values, and thanks to their dedication to supporting a worthy cause, sales have raised over £20,000 for CALM, supporting more than 2500 potentially life-saving phone calls.

Mental health isn’t the only battle the brand has faced, like every other CBD company in the UK, the duo have had to face the challenges presented by the FSA’s decision to regulate CBD as a novel food. “We’d like to think that the industry is emerging from the confusion, but we still have doubts. There seems to be little consensus and a significant amount of political manipulation in the regulation of the cannabis industry. We have faith in our network of suppliers to help us achieve novel food listing, but we also see this as an opportunity for multi-million-pound conglomerates to come along and snap up the market with endless pockets. As two guys with a phone and a laptop each, we have no way to compete. We need to play to our strengths.”

Undeterred, both Ian and Sam plan to continue putting as much love into the brand and the products they produce, but do they have anything else in store? “In a recent conversation, somebody brought up the fact that ‘fortune favours the brave’ – we are in the process of developing a full-on recreational cannabis brand with huge aspirations. We are accumulating everything we’ve learned over the years and investing it with a larger team who work across the globe. Watch this space…”



from leafie https://www.leafie.co.uk/articles/cbdiablo-brand-feature/
via IFTTT

source https://mairapostema.tumblr.com/post/682232970240802816

Hempcrete Gets a Boost From the International Code Council

TESTSTSARDSAR

Hempcrete Gets a Boost From the International Code Council by Frank Schuler

The hemp plant can be made into more things than just about any other plant on earth. The number of things that hemp can be made into is well into the thousands, with some estimates being as great as 50,000 unique items that can be created from the material.

While virtually every item that hemp can be made into benefits humankind, one product is particularly useful – hempcrete. Hempcrete, sometimes referred to as hemp-lime, is a bio-composite made of the woody inner core of the hemp plant mixed with a lime base that serves as a binder.

The hemp plant’s core (called the ‘shiv’) has a large silica content, which is why it bonds well with lime. Hempcrete can be used as a building material for various types of structures, primarily as an insulation material that pairs well with wood framing.

Hempcrete is exponentially lighter than concrete, is more fire-resistant than most other comparable building materials, and is carbon negative, meaning that it takes more carbon out of the air than it puts into it.

Earlier this week hempcrete received a recommendation from the International Code Council to add hempcrete to its International Residential Code. The recommendation moves hempcrete a step closer to formal adoption as an officially recognized residential building material.

“The International Code Council is the leading global source of model codes and standards and building safety solutions that include product evaluation, accreditation, technology, training, and certification,” according to its website.

“The Code Council’s codes, standards, and solutions are used to ensure safe, affordable, and sustainable communities and buildings worldwide,” the Council’s website said.

While the International Code Council is based in the United States, aspects of its official International Residential Code have been adopted around the world, and officially adding hempcrete to it will result in hempcrete being used more often than it is now, and that is obviously good news.

Hemp production has risen considerably around the world in recent years, mostly due to the rise in the popularity of CBD products. However, as hempcrete continues to be used more often by builders around the globe, hempcrete will likely prove to be a driving force for increased hemp production itself.

This article was originally published on InternationalCannabisChronicle.com. Header image “Hempcrete Studio.” by tomline43 is marked with CC BY 2.0.

A link to your site, with your site’s name and description as anchor text.



Via https://cannatechtoday.com/hempcrete-gets-a-boost-from-the-international-code-council/


source https://renzverspaget.weebly.com/blog/hempcrete-gets-a-boost-from-the-international-code-council

source https://renzverspaget.tumblr.com/post/682228392885649408

source https://mairapostema.tumblr.com/post/682231813707612160

CBD and Skin: A Comprehensive Report

The discovery of a skin endocannabinoid system and its role in maintaining skin homeostasis has raised interest in the use of cannabinoids for the treatment of different skin conditions.

The disturbances of the endocannabinoid system and its regular actions can contribute to the development of pathological skin disorders, so cannabinoids might be the answer to certain diseases like acne, eczema, dermatitis, and psoriasis.

In the skin, CB1 and CB2 receptors have been found in numerous types of cells — epidermal keratinocytes, melanocytes, dermal cells, mast cells, sweat glands, hair follicles, and cutaneous nerve fibers. All of these areas present potential targets for future topical drugs or cosmetics based on CBD formulations.

Unfortunately, even with the growing enthusiasm in the industry and among the consumers, and with the proven anti-inflammatory effects of CBD, there is still not much clinical evidence on the benefits of CBD in the potential treatment of numerous skin disorders, and some research is financed by the industry itself.

CBD and skin: CBD might help with acne

One such example is a 2019 phase 2 clinical study on 368 patients with moderate to severe acne. The trial lasting 12 weeks found that CBD showed a strong impact on inflammatory lesions and an even stronger effect on non-inflammatory lesion reduction. This research is adding more weight to the claim that CBD could effectively treat acne, although more research is needed to confirm the results.

A phase 1 study in 23 volunteers aged 18 to 65 years with moderate to severe acne showed that a 5% formulation of CBD when applied twice daily for four weeks to the entire face brings a considerate promise to a novel use of CBD in the treatment of the skin.

These findings might point in a similar direction as small previous research on 11 patients, which found that 3% cannabis seeds extract cream was significantly effective in the reduction of skin sebum and erythema. (The skin sebum is an oily substance produced by the sebaceous glands, and erythema is a skin rash caused by inflamed blood capillaries.)

Similar to the aforementioned research, where Cannabis Sativa seeds extract cream has been used, in a study on 20 patients with atopic dermatitis, skin dryness and itchiness significantly improved after intake of dietary hempseed oil for 20 weeks. However, the patients in this trial used the hempseed oil orally and not topically, and there is a difference in bioavailability in the different forms of cannabinoid intake. Also, in modern cannabinoid formulations, hempseed oil is mostly used as base oil, and not the active ingredient. Nevertheless, it is another human study showing promising results of cannabis products in treating atopic dermatitis.

However rare the studies on topically administrated CBD are, they are not nonexistent. The effect of CBD on dermal nerve fibers was confirmed in a study on 18 participants with an experimentally induced itch that was significantly reduced by applying CBD-containing skin patches.

CBD might help with eczema, dermatitis and psoriasis

An observational study looking into the effects of CBD on individuals with self-reported eczema also showed promising results — out of 16 patients applying CBD gel for two weeks, 67% reported a decrease in itch and 50% perceived an improvement in their eczema by more than 60%. Moreover, the patients noted a reduction in the psychosocial and emotional burden of eczema.

Another trial confirmed that the topical administration of CBD ointment is a safe and effective alternative for the improvement of the quality of life in patients with the most common skin diseases. The spontaneous, anecdotal, retrospective study investigated changes in 20 patients with psoriasis, atopic dermatitis, and resulting outcome scars. The patients were instructed to administer topical CBD-enriched ointment to lesioned skin areas twice daily for three months of treatment. As a result, skin elasticity and hydration improved, while blemishes and scars were reduced. The topical product also improved the severity of itches as well as the consequent loss of sleep in patients with atopic dermatitis. The product used in this study contained CBD seed oil and natural ingredients, including Mangifera Indica, Calendula officinalis, Lavendula officinalis, Chamomile, Amyris Balsamifera, and Shea butter.

Furthermore, scientists found that replacing current shampooing practices with a broad-spectrum CBD-containing shampoo significantly reduces the severity and symptoms of scalp inflammation within two weeks of use. A study on 50 people aged 18-61 years with mild or moderate cases of scalp psoriasis and seborrheic dermatitis showed that CBD could be highly effective in reducing symptoms of both diseases. Apart from the broad-spectrum CBD, the shampoo ingredients have included ketoconazole and numerous ingredients that promote hair growth. After two weeks, scalp inflammation (arborizing vessels, twisted capillaries, and scales), as well as the symptoms of erythema and scaling, itching, and burning were reduced in all participants.

CBD could help with rare and painful diseases

There are records of the use of topical CBD to treat a rare and painful skin condition in children, epidermolysis bullosa. One of them is the case of a six-month-old boy who suffered from blisters on the lower part of his body and whose parents self-initiated the treatment with CBD spray containing CBD tincture two to three times a day. From the start of the treatment, the parents noticed a reduction in blisters and faster healing of chronic wounds. Also, there was no more need for morphine before the dressing changes.

The second case is of a three-year-old girl whose mother began using a blend of emu oil and CBD oil to treat blisters on her face, trunk, and extremities at least twice daily, after which she had fewer blisters, and the healing time for facial blisters was reduced by approximately half. The application of CBD also reduced pain, allowing the child to walk longer distances.

In the third case, the child treated with CBD was a 10-year-old boy in whom blistering around the neckline had first been noticed at one month of age, and blisters on the palms and soles progressed at approximately 13 months of age when he began walking. His parents self-initiated CBD oil and cream topically to his blisters and noted a significant reduction in blisters. There was also a reduction in pain, leading to less wheelchair use, and he was able to discontinue the previous therapy.

The photographs accompanying these reports witness the dramatic improvement in the state of children’s skin health.

CBD and skin: CBD could help with wound closure

There is scientific evidence that CBD could help with wound closure in previously non-healing or recurring wounds. Patients who experience such conditions are, for example, patients with calciphylaxis. It is a rare disease in which calcium accumulates in small blood vessels of the fat and skin tissues and causes blood clots, painful skin ulcers, and may cause serious infections that can lead to death. In a multicohort open-label trial, 32 participants with calciphylaxis, received topical CBD (3.75 mg/ml) and minimal Δ9-THC (<1 mg per day), which was applied to wound beds and peri-wound tissues. Wound closure was achieved in 90% of cases after one year of treatment.

CBD was also found to have great potential in rapid wound closure of previously non-healing venous leg ulcers. In a prospective open-label cohort trial on 11 patients, a formulation containing CBD 3.8 mg/ml, THC <1 mg/ml, Quercetin 31.3 mg/ml, Diosmin 25.3 mg/ml, Hesperidin 2.5 mg/ml and Beta-Caryophyllene 152.7 mg/ml in the base carrier containing Hyaluronic acid + Aloe Vera Gel (1/1 v/v) led to complete wound closure in 79% of the patients and 81% of the wounds within 34 days.

CBD for Venous Leg Ulcers: Complete Wound Closure in 81% Chronic Cases

In healthy volunteers, hemp extract was found to promote the hydration of the skin, suggesting that cannabinoids in cosmetics might act as natural moisturizers. After treating skin with a substance that causes it to dry substantially, scientists applied hydrogels containing 0.5%, 1%, and 5% of hemp extract. After five hours, the treated skin returned to its normal state, with the moisturizing effects rising with the higher extract percentage. The addition of hemp extracts in the formulation of hydrogels has shown an influence on the restoring of the hydrolipid balance and the rebuilding of the hydrolipid barrier of the skin. Scientists have concluded that hemp extracts can be a valuable source of biologically active substances that reduce oxidative stress, inhibit skin aging processes and positively affect the viability of skin cells.

CBD regulates 163 genes in the skin

A study examining the mechanisms of action of topical application of CBD showed that CBD regulates a number of genes in the skin. Genemarkers, a company specializing in clinical genomics testing and genomics research services has conducted an in vitro study on a skin model containing keratinocytes and fibroblasts with an ex vivo skin tissue system. Observing the biological efficacy of CBD extracts and cosmetic formulas containing them, they found that CBD regulates 163 genes:

14 related to wound healing and growth factors;
7 connected with skin hydration;
15 related to skin barrier integrity;
17 relevant to pigmentation;
23 linked to inflammation and immune response;
13 involved in extracellular matrix breakdown and barrier integrity;
7 relevant for acne regulation;
6 connected with anti-aging functions;
15 linked to antioxidant and stress responses;
11 related to cell renewal and regeneration;
8 related to regulating the circadian rhythm;
2 related to the endocannabinoid system, and
25 involved in epidermal barrier formation.

They determined that the changes in gene expression in response to CBD occur over time, with fewer changes at early time points of three and six hours, and with 24 or 48 hours as the most relevant time points for identifying changes.

At the molecular level, in keratinocytes, CBD targets a protein called BACH1 that regulates the expression of antioxidant and anti-inflammatory genes. The same protein is a therapeutic target for lung and breast cancer.

CBD and skin: The potential of PEA

Some thorough reviews on the effects of cannabis-based products on the skin include human studies that used palmitoylethanolamide (PEA). PEA is an endocannabinoid-like lipid mediator with anti-inflammatory, analgesic, and neuroprotective properties. It has a multi-modal mechanism of action, primarily activating the nuclear receptor PPAR-α and potentially working through the endocannabinoid system (ECS). Since it targets similar pathways as CBD, it is interesting to look into its benefits for the skin. For example, PEA was found to improve the symptoms of eczema, decrease the use of topical steroids in atopic dermatitis, eliminate itching in full in 38% of cases of chronic pruritus, and reduce the dryness of the skin in 81% of patients.

The anti-inflammatory effects of CBD are mediated through direct modulation of the immune system, while PEA enhances endogenous cannabinoids. The presence of PEA in topical CBD did not show any signs of skin irritation or sensitization with the concentrations of CBD from 0.1% up to 10% in healthy humans. Mild phototoxic reactions were found with a cream product featuring hemp seed oil, containing little to no detectable CBD or PEA. This peculiar finding is puzzling because essential oils have been shown to be phototoxic, but fatty acids from hemp seed oil have not been demonstrated to be phototoxic in either animals or humans, so found phototoxicity could be due to other ingredients in the formulation in question.

Protective action of CBD against UV radiation

UV radiation decreases the level of endocannabinoids in skin cells and enhances the expression of membrane endocannabinoid receptors CB1, CB2, and TRPV1, influencing the cytoprotective and proinflammatory properties of these cells. For that reason, CBD might be a promising agent for protecting skin cells against UV radiation.

A study analyzing the effects of CBD on keratinocytes exposed to UVA and UVB radiation in a 3D system found that CBD shows a series of positive actions that stimulate skin cells to prevent the harmful effects of such radiation. These include antioxidant and anti-inflammatory activity, regulation of protein biosynthesis and degradation, and control of enzyme activity by structural modification. However, further research is required to elucidate its long-term use in epidermal cells.

In rats, it is found that topical application of CBD to the skin, when exposed to UV radiation, helps normalize the expression of keratinocyte proteins. As UV therapy is a part of the treatment of skin diseases like psoriasis, CBD might be useful as a protective factor to reduce the metabolic changes in keratinocytes caused by UV radiation. After the beneficial effect of CBD on psoriasis-induced skin lesions has been confirmed, this could be another reason for more research in this field.

So far, it has been found that CBD treatment intensifies some changes, like phospholipid content and membrane charge, caused by the radiation of psoriatic cells, while it prevents these changes in the cells of healthy people.

CBD and skin: The double effect of CBD on pigmentation and melanoma

Another compelling research area is the effects of CBD on pigmentation and skin cancer. The pigmentation comes as a manifestation of the synthesis of dark pigment, melanin. The involvement of ECS pathways in melanin-producing cells melanocytes is found to be complex, with somewhat controversial results in so far conducted preclinical trials.

CBD was found to have a double effect on human melanocytes. At low concentrations, through CB1 receptors, it induces the process for the production of melanin, and at high concentrations, through TRPV1 receptors, it induces cell death, which could be useful in treating skin cancer.

CBD might be beneficial for hair growth

The analysis of human skin revealed the presence of CB1 and CB2 receptors within the hair follicle. CB1 was detected in portions of the infundibulum and the inner root sheath, and CB2 was found in the outer root sheath and hair bulb.

The discovery led to research on the potential of CBD in promoting hair growth. The enthusiasm was further fueled by the results of a trial on obese mice, when orally administered synthetic antagonist of CB1 promoted hair growth in that rodent model.

However, different studies point to the conclusion that hair growth induced by CBD is strictly dose-dependent. Promising results came from a case study on 35 people using topical hemp extract with 3-4 mg of CBD once daily. The results have shown a 93.5% increase in hair growth after six months. The topical extract in question has been made of high CBD cannabis Sativa flower ultra-pulverized into a fine powder containing 10.78% CBD, and 0.21% THC.

3-4 Mg of CBD Once a Day Brings 93.5% Increase in Hair Growth

The post CBD and Skin: A Comprehensive Report appeared first on ilesol.


from ilesol https://ilesol.com/cbd-and-skin-a-comprehensive-report/

source https://mairapostema.tumblr.com/post/682225491075301376

Thursday 21 April 2022

European Cannabis Week Coming to Germany in July 2022

TESTSTSARDSAR

European Cannabis Week Coming to Germany in July 2022 by Johnny Green

The European continent is the most exciting place for cannabis industry pursuits and policy reform efforts right now, and Germany is at the heart of it. Having served as the medical cannabis industry capital of Europe in recent years, Germany is trending towards full adult-use legalization and the launch of legal adult-use cannabis sales. When that happens, Germany will further become the undisputed cannabis industry capital of Europe.

Malta made history late last year when it became the first European nation to legalize cannabis for adult use, and just the third country on earth to make the policy shift. Yet, whereas Malta will not permit legal adult-use sales as part of its legalization model, Germany’s eventual legalization model will include sales according to current proposals from the governing coalition.

Related projections for Germany’s emerging cannabis industry are off the charts. To put Germany’s industry potential into perspective, consider the fact that Germany’s population is roughly twice the size of Canada, Uruguay, and Malta’s populations combined. Furthermore, Germany’s economy, which is the fourth-largest economy on earth, is well over twice the size of the three current legal cannabis nations’ economies combined.

It’s truly an amazing time to be a cannabis enthusiast in Europe, and particularly so in Germany, which is why we are so excited to announce European Cannabis Week in Berlin in July. The International Cannabis Business Conference, the largest and longest-running cannabis B2B event in Europe, is teaming up with Mary Jane Berlin Expo, Germany’s largest cannabis expo, to provide a week of amazing cannabis industry, policy, and entertainment opportunities.

European Cannabis Week will kick off on July 15, 2022 with the start of the Mary Jane Berlin Expo. In Europe, no cannabis expo is growing as fast as the Mary Jane Berlin: Over 220 exhibitors are expected at the event, along with over 27,000 attendees at the venue Arena Berlin & Badeschiff. The Mary Jane Berlin Expo will take place July 15-17th and combines a product exhibition, congress and festival in one. The range of products includes CBD, hemp oil, fertilizer, snacks, vaporizers, dog food, textiles and much more presented on a total area of over 13,000 square meters.

What makes Mary Jane Berlin stand out from other expos is its diverse cultural and entertainment program. The Mary Jane Berlin Festival measures the largest outdoor area ever to be offered by a European cannabis expo: Two festival stages play live music and live acts, the street food area offers culinary (cannabis) highlights and a sandy beach with an infinity pool in the famous Berlin river Spree provides a place to cool off in the hot summer days.

Below is a preview video for the upcoming Mary Jane Berlin event:

“We are particularly excited about European Cannabis Week given the favorable political climate for cannabis legalization in many parts of the continent. It is going to be extra special for our team to offer world-class cannabis industry and policy education, networking, and entertainment to attendees alongside Mary Jane Berlin at such a crucial juncture for Europe’s cannabis community,” says Alex Rogers, founder of the International Cannabis Business Conference.

After the Expo, European Cannabis Week then transitions to the International Cannabis Business Conference which is hosting one of its industry-leading Global Investment Forums on July 18th in Berlin. The Global Investment Forum in Berlin will feature hand-picked cannabis companies participating in a pitch session in front of top investors on the Main Stage.

It is a tremendous opportunity for cannabis companies in the emerging cannabis industry to showcase their products/services in front of seasoned industry investors. The pitch session is also open to service providers looking for reliable and high-end clients.

“We know how hard it is for quality investors to link up with vetted cannabis industry companies offering valuable investment opportunities,” Rogers stated. “That is why we are bringing the Global Investment Forum back to Berlin. It will be a prime networking opportunity for cannabis industry investors, entrepreneurs, and industry service providers alike.”

Following the Global Investment Forum is the two-day International Cannabis Business Conference Berlin B2B event that begins on July 19th. Cannabis industry leaders, policymakers, entrepreneurs, and industry service providers from over 80 countries will be in attendance at the B2B event, making it the perfect place to learn and network. Below is a recap video of last year’s Berlin events:

At the conclusion of the B2B event, attendees will then be able to enjoy one of the International Cannabis Business Conference’s famous after-parties. This year’s B2B event after-party in Berlin will feature the multi-Grammy award-winning reggae band Morgan Heritage. After a long week of learning from true-cannabis experts and networking with cannabis enthusiasts from around the globe, the after-party featuring Morgan Heritage is the perfect way to cap off European Cannabis Week.

The International Cannabis Business Conference is the leading B2B cannabis event series on earth. Events have been held in the United States, Canada, Spain, Germany, and Switzerland. Additional locations in other countries are being identified and will be announced in the future. The topics covered at the Global Investment Forum and conference via panels and presentations will be led by the top cannabis experts in the global cannabis space. Speaker and schedule announcements will be released soon.

European Cannabis Week is going to be the ultimate cannabis experience in the heart of Germany during the middle of summer. Make sure that you don’t miss out and get your tickets to Mary Jane Berlin and the International Cannabis Business Conference as soon as possible before tickets sell out!

This article was first published on InternationalCannabisChronicle.com.

A link to your site, with your site’s name and description as anchor text.



Via https://cannatechtoday.com/european-cannabis-week-coming-to-germany-in-july-2022/


source https://renzverspaget.weebly.com/blog/european-cannabis-week-coming-to-germany-in-july-2022

source https://renzverspaget.tumblr.com/post/682167959712661505

source https://mairapostema.tumblr.com/post/682171442709872640

Gut feelings – the intriguing connection between psychedelics and the microbiome

If you’ve ever had to “trust your gut”, you know just how strong the connection between the mind and the body is. When you sense that knot in your stomach and the nervous butterflies start, it can definitely feel as though you have a brain in your belly, but that gut feeling is more reliable than you think. 

For years, scientists have endeavoured to understand the mysterious relationship between the gut and our mind. It goes beyond emotions; there is even accumulating evidence to suggest a connection between our gut health and mental state. A decline in one often worsens the other, so why aren’t they being treated as one? 

As the field of psychedelic medicine begins to flourish, perhaps the mind-altering effects of these drugs could stretch to our second brain.

The microbiome controls the mind

Before we delve into the mysterious relationship between our gut and mental health, let’s go over the basics. What is the microbiome, and why is it so important?

The term microbiome refers to the collection of microorganisms that colonise our body, consisting of bacteria, archaea, viruses, and fungi. The diversity of our gut microbiome, or the balance of our “good” and “bad” bacteria, is a major predictor of our health and wellbeing. It has even been shown to influence our brain function and behaviour. 

Our gut bacteria actually help to regulate the production of serotonin in the digestive tract – 95% of our body’s serotonin, in fact. Not only is serotonin involved in modulating various gastrointestinal (GI) processes, but it is also a crucial regulator of our mood, cognition, appetite, sleep, and immune health. Hence, it is often referred to as our “happy hormone”.

The gut and the brain are, therefore, inextricably linked. This connection, termed the gut-brain axis, refers to all of the hormonal and neurological pathways that tie the brain to the gut, mediated by the vagus nerve. It’s a two-way street; mood disturbances can throw off our gut health, just as imbalances in our microbiome (known as dysbiosis) can hinder our brain function. 

The gut-brain axis is a fascinating relationship that is often overlooked. For instance, it’s not uncommon for people with irritable bowel syndrome (IBS) to experience anxiety and depression, but since the gut isn’t necessarily the obvious culprit for poor mental health, this can make it hard for people to pinpoint the root of their problems.

Intriguingly, it has also been noted that selective serotonin reuptake inhibitors (SSRIs), common forms of antidepressants, offer therapeutic benefits in various GI disorders. This has led some researchers to speculate that emerging mental health therapies could also help to support our physical health and wellbeing – and this is where psychedelics come in.

A psychedelic trip – can you stomach it?

Research into psychedelic drugs is experiencing a renaissance, and evidence in favour of their use in treating countless mental health conditions is piling high. Psychedelic-assisted therapy is a revolutionary approach to mental health. It helps patients to address the true source of their problems which, unlike leading drugs, prioritises healing from within.   

There is a fascinating crossover between the conditions being studied and treated with psychedelic therapy and those associated with dysfunctional gut health. Depression, anxiety, and post-traumatic stress disorder (PTSD), among others, have all been linked to microbial dysbiosis in the gut. They, too, appear to respond to psychedelic therapy. So, could the gut play a role in a psychedelic trip?

Most people with experience of using psychedelics will say, without a doubt, yes. Abdominal discomfort, nausea, and even vomiting are surprisingly common features of the psychedelic experience. In ayahuasca ceremonies, this is a crucial element of the healing process, where so-called “purging” is seen as expulsion of trauma or negativity.

It is thought that the gastrointestinal side effects of psychedelics are due to their ability to activate serotonin 2A (5-HT2A) receptors, the same receptors responsible for the hallucinogenic effects of psychedelics in the brain. 

So it’s clear that psychedelics do something to our gut. The extent of exactly what isn’t yet known, but “if, in fact, psychedelics are having an impact on good bacteria or bad bacteria [in the gut], then that impact—in either changing the numbers or changing the function of those bacteria—could have a positive impact on anxiety, depression, or GI disorders,” Jane Foster, a microbiome researcher, tells Vice

Healing from within

Scientists have begun to investigate whether this gut-brain connection could be enhanced using psychedelics. Would it be possible to heal the gut through the mind, and vice versa?

Researchers Dr Kate Pate and Dr Christopher Lowry believe so. They are working with the Heroic Hearts Project to understand the effects of ayahuasca ceremonies on the microbiome and how this could influence PTSD symptoms in veterans.  

Previous research has highlighted a substantial link between inflammation and PTSD. The exact mechanisms are not yet known, but Pate and Lowry suggest that stress and trauma reduce the diversity of the microbiome, making the gut more vulnerable to pathogens and, thus, more likely to become inflamed. Gut inflammation, also known as “leaky gut”, can cause bacteria to enter the body and trigger systemic inflammation. 

There is also evidence to suggest that inflammation can exacerbate PTSD symptoms, suggesting that gut dysbiosis is both a cause and consequence of poor mental health. Although this hasn’t been tested experimentally, Pate and Lowry believe that “an altered microbiome may play a role in the transformative effects of ayahuasca.” 

Another researcher, Dr Kim Kuypers, has offered a similar theory. She proposes that the positive effects seen with microdosing psychedelics could have more to do with the gut than previously credited, suggesting that “low doses of psychedelics induce their effects via alterations in the microbiome and related pathways to the brain.” 

Currently, there is no experimental evidence to support this theory, but Kuypers’ paper highlights a need for further research into the mechanisms underlying the therapeutic benefits of psychedelics. Perhaps the gut-brain axis is more involved than we think.

There are far more questions than answers when it comes to psychedelics and gut health. It may be that these drugs can directly reduce inflammation through 5-HT2A receptor activation in the gut and, in turn, improve symptoms of mental health conditions. Or, alternatively, the improvements in brain function seen with psychedelic therapy could have positive downstream effects on gut health. But until the underlying mechanisms are fully investigated, the details of the gut-brain relationship remain a mystery.



from leafie https://www.leafie.co.uk/articles/gut-feelings-connection-psychedelics-microbiome/
via IFTTT

source https://mairapostema.tumblr.com/post/682161254999146496

Switzerland to begin recreational cannabis trial this summer

Switzerland is to begin a pilot scheme that will allow adults to buy cannabis legally for recreational use. The pilot scheme, announced last year, will launch in the city of Basel this summer, with other cities such as Zurich, Geneva, and Bern to follow later in the year.

Under the pilot scheme, 400 adults in the city will be able to register to buy cannabis from selected pharmacies. The scheme has been designed to better understand “alternative regulatory forms” such as regulated sales at official vendors, according to the Federal Office of Public Health.

The scheme will last for 2 and a half years, during which participants will be questioned regularly to find out what effect the substance is having on their mental and physical health.

It is estimated that around 500,000 adults in Switzerland consume cannabis. The country decriminalized small scale possession in 2012. Anyone caught with less than 10 grams of cannabis is not prosecuted, but instead issued with a fine of 100 Swiss Francs. The country also allows the sale of ‘light’ cannabis, containing no more than 1% THC, which can be legally bought over the counter from tobacco stores.

The cannabis for the pilot scheme will be produced by Swiss supplier Pure Production, which has been granted a licence to legally produce and process plants by the Swiss authorities for research purposes. Anyone on the pilot scheme caught passing on or selling the cannabis will be penalised and kicked out of the project, the Federal Office of Public Health said.



from leafie https://www.leafie.co.uk/news/switzerland-recreational-cannabis-trial-this-summer/
via IFTTT

source https://mairapostema.tumblr.com/post/682149912230625280

Wednesday 20 April 2022

RE Botanicals Product Catalog

RE Botanicals sells products in four different categories:

  • Tinctures
  • Relief Body Oil
  • Capsules
  • Pets

All of the company’s products are made with full-spectrum hemp extract, meaning it contains cannabinoids (like CBD), terpenes, fatty acids, flavonoids, vitamins, and minerals.

There will likely be trace amounts of THC, all within the legal limit for hemp (<0.3%).

As of November 2019, RE Botanicals significantly lowered the prices of their products.

Here’s an overview of all the products RE Botanicals offers:

Category
Price
Concentration
# of Products
CBD Oil/Tinctures From $9.99 From 150mg 9
Relief Body Oil From $29.99 From 200mg 5
Capsules From $14.99 From 150mg 3
Pets $29.99 300mg 1

Tinctures

RE Botanicals offers several options for their CBD oil, some with their classic flavor:

  • Hemp 15mg Classic Tincture 30ml
  • Hemp 25mg Classic Tincture 6ml
  • Hemp 25mg Classic Tincture 30ml
  • Hemp 25mg Classic Tincture 100ml
  • Hemp 50mg Classic Tincture 30ml

They also sell others with peppermint flavor:

  • Hemp 15mg Peppermint Tincture 30ml
  • Hemp 25mg Peppermint Tincture 30ml
  • Hemp 25mg Peppermint Tincture 100ml

The oils have a certified organic MCT oil base, and the Peppermint tinctures are blended with USDA-certified organic peppermint oil.

Best Use: Tinctures seem to offer the broadest range of potential benefits among all types of CBD products. 

Hemp 15mg Classic Tincture 30ml

15mg Classic Tincture 30ml

Concentration

450mg (15mg/serving)

Value

$39.99 ($0.089/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract

Hemp 25mg Classic Tincture 6ml

25mg Classic Tincture 6ml

Concentration

150mg (25mg/serving)

Value

$9.99 ($0.067/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract

Hemp 25mg Classic Tincture 30ml

25mg Classic Tincture 30ml

Concentration

750mg (25mg/serving)

Value

$59.99 ($0.08/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract

Hemp 25mg Classic Tincture 100ml

25mg Classic Tincture 100ml

Concentration

2,500mg (25mg/serving)

Value

$129.99 ($0.052/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract

Hemp 50mg Classic Tincture 30ml

50mg Classic Tincture 30ml

Concentration

1,500mg (50mg/serving)

Value

$99.99 ($0.067/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract

Hemp 15mg Peppermint Tincture 30ml

15mg Peppermint Tincture 30ml

Concentration

450mg (15mg/serving)

Value

$39.99 ($0.089/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract, Organic Mentha Piperita (Peppermint) Oil

Hemp 25mg Peppermint Tincture 30ml

25mg Peppermint Tincture 30ml

Concentration

750mg (25mg/serving)

Value

$59.99 ($0.08/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract, Organic Mentha Piperita (Peppermint) Oil

Hemp 25mg Peppermint Tincture 100ml

25mg Peppermint Tincture 100ml

Concentration

2,500mg (25mg/serving)

Value

$129.99 ($0.052/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract, Organic Mentha Piperita (Peppermint) Oil

Hemp 50mg Peppermint Tincture 30ml

50mg Peppermint Tincture 30ml

Concentration

1,500mg (50mg/serving)

Value

$99.99 ($0.067/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Extract, Organic Mentha Piperita (Peppermint) Oil

Relief Body Oil

RE Botanicals sells five different Relief Body Oils:

  • Lavender
  • Peppermint
  • Ginger Lime
  • Extra Strength Lavender
  • Extra Strength Mandarin Turmeric

The regular strength Relief Body Oils contain 200mg of CBD, while the Extra Strength has 500mg.

Best Use: These roll-ons are best for targeting point-specific discomfort, either from exercise-induced inflammation or occasional aches.

Relief Body Oil Lavender

Relief Body Oil Lavender

Concentration

200mg (10ml)

Value

$29.99 ($0.15/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Oil Extract, Organic Lavandula Angustifolia (Lavender) Oil, Organic Lavandula Hybrida (Lavandin) Oil

Relief Body Oil Peppermint

Relief Body Oil Peppermint

Concentration

200mg (10ml)

Value

$29.99 ($0.15/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Oil Extract, Organic Mentha Piperita (Peppermint) Oil

Relief Body Oil Ginger Lime

Relief Body Oil Ginger Lime

Concentration

200mg (10ml)

Value

$29.99 ($0.15/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Oil Extract, Organic Citrus Aurantifolia (Lime) Oil, Organic Zingiber Officinale (Ginger) Root Oil

Extra Strength Relief Body Oil Lavender

Extra Strength Relief Body Oil Lavender

Concentration

500mg (10ml)

Value

$39.99 ($0.08/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Oil Extract, Organic Lavandula Angustifolia (Lavender) Oil, Organic Lavandula Hybrida (Lavandin) Oil

Extra Strength Relief Body Oil Mandarin Turmeric

Extra Strength Relief Body Oil Mandarin Turmeric

Concentration

500mg (10ml)

Value

$39.99 ($0.08/mg)

Ingredients

Organic MCT Coconut Oil made from organic young coconuts, Organic Hemp Oil Extract, Organic Curcuma Longa (Turmeric) Oil, Organic Citrus Nobilis (Mandarin Orange) Peel Oil

Capsules

All of RE Botanicals capsules contain 15mg of CBD, but they come in three different sizes:

  • 10 servings
  • 30 servings
  • 60 servings

The capsules are vegan and contain the same ingredients as the classic tinctures.

Best Use: Capsules are best for those who do not like the taste of CBD oil while offering nearly the same range of benefits as tinctures.

Hemp 15mg Classic Capsules (10 servings)

15mg Classic Capsules 10 servings

Concentration

150mg (15mg/serving)

Value

$14.99 ($0.10/mg)

Ingredients

Organic Hemp [aerial parts] CBD Extract, Organic Virgin Coconut Oil, Vegan Capsule (Vegetable Cellulose, Water)

Hemp 15mg Classic Capsules (30 servings)

15mg Classic Capsules 30 servings

Concentration

450mg (15mg/serving)

Value

$39.99 ($0.089/mg)

Ingredients

Organic Hemp [aerial parts] CBD Extract, Organic Virgin Coconut Oil, Vegan Capsule (Vegetable Cellulose, Water)

Hemp 15mg Classic Capsules 60 servings

15mg Classic Capsules 60 servings

Concentration

900mg (15mg/serving)

Value

$59.99 ($0.067/mg)

Ingredients

Organic Hemp [aerial parts] CBD Extract, Organic Virgin Coconut Oil, Vegan Capsule (Vegetable Cellulose, Water)

Pets

RE Botanicals offers a less concentrated form of CBD oil for pets that contains the same ingredients as the human tinctures.

The company provides a chart of recommended serving sizes for pets of various sizes that you can see here.

Best Use: CBD oil for pets is best used to calm hyperactivity, support healthy bones and joints, among other potential benefits.

Hemp Tincture for Pets 30ml

Tincture for Pets 30ml

Concentration

300mg

Value

$29.99 ($0.10/mg)

Ingredients

Organic Hemp [aerial parts] CBD Extract, Organic Virgin Coconut (MCT) Oil



via The CBD Insider https://thecbdinsider.com/news/re-botanicals-product-catalog/#utm_source=rss&utm_medium=rss&utm_campaign=re-botanicals-product-catalog


source https://renzverspaget.weebly.com/blog/re-botanicals-product-catalog

source https://renzverspaget.tumblr.com/post/682081152462405632

source https://mairapostema.tumblr.com/post/682088362079911936

Meet CBDiablo, the brand doing good by being a little bit bad

“Sleepless nights, endless stress, and the monthly merry-go-round of shit.” If you’ve ever run your own business, you will know it can be an...